INTERGROWTH-21st in China

30th November 2015 • comment

Preterm birth has been difficult to study and prevent because of its complex syndromic nature. The INTERGROWTH-21st Project presents a new approach to this problem. This paper explains the results of the first application of a prototype classification system for preterm birth based on twelve phenotypes, using data from the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project.

6th January 2015 • comment

The INTERGROWTH-21st Neurodevelopment Package is a multi-dimensional instrument measuring early childhood development (ECD). Its developmental approach may be useful to those involved in large-scale ECD research and surveillance efforts. This paper describes neurodevelopment tools for preschoolers and the systematic approach leading to the development of the Package. The Package measures vision; cortical auditory processing; and cognition, language skills, behavior, motor skills, and attention in 35-45 minutes. Sleep-wake patterns are also assessed. Tablet-based applications with integrated quality checks and automated, wireless electroencephalography make the Package easy to administer in the field by non-specialist staff.

1st December 2014 • comment

The INTERGROWTH-21st Project has produced the first, international standards for relating fetal crown-rump length to gestational age. 

25th September 2014 • comment

These international anthropometric standards were developed to assess newborn size in routine clinical practice that are intended to complement the WHO Child Growth Standards and allow comparisons across multiethnic populations.

5th September 2014 • comment

Using the same methods and conceptual approach as the WHO child growth standards, the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project developed international growth and size standards for fetuses for clinical interpretation of routinely taken ultrasound measurements and for comparisons across populations.

5th September 2014 • comment

Large differences exist in size at birth and in rates of impaired fetal growth worldwide. The relative effects of nutrition, disease, the environment, and genetics on these differences are often debated. In clinical practice, various references are often used to assess fetal growth and newborn size across populations and ethnic origins, whereas international standards for assessing growth in infants and children have been established. In the INTERGROWTH-21st Project, our aim was to assess fetal growth and newborn size in eight geographically defined urban populations in which the health needs of mothers were met and adequate antenatal care was provided. Through the Fetal Growth Longitudinal Study and Newborn Cross-Sectional Study, data showed that fetal growth and newborn length are similar across diverse georgraphical settings when mothers' nutritional and health needs are met, and environmental constraints on growth are low. The findings for birthlength are in strong agreement with the WHO Multicentre Growth Reference Study (MGRS). These results provide the conceptual frame to create international standards for growth from conception to newborn baby, which will extend the present infant to childhood WHO MGRS standards. Download the PDF of the article here

7th July 2014 • comment